MYH11 (Gene)

Organism:

Homo sapiens

Synonyms:AAT4, ENTREZ:4629, FAA4, HGNC:7569, MIM:160745, MYH11, NM_001040113, NM_001040114, NM_002474, NM_022844, NP_001035202, NP_001035203, NP_002465, NP_074035, SMHC, SMMHC, XM_011522502, XM_017023250, XP_011520804, XP_016878739, myosin heavy chain 11

Id:ENSG00000276480

Description:myosin heavy chain 11 [Source:HGNC Symbol;Acc:HGNC:7569]

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MYH11's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with MYH11.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MYH11.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MYH11.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MYH11.

Results found

Linked to

	Label	Description
	Colitis Phenotype (Entity type)	Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the ...
	Hypertension Phenotype (Entity type)	The presence of chronic increased pressure in the systemic arterial system.
	Abdominal aortic aneurysm Phenotype (Entity type)	An abnormal localized widening (dilatation) of the abdominal aorta.
	Peripheral arterial stenosis Phenotype (Entity type)	Narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quan...
	Sepsis Phenotype (Entity type)	Systemic inflammatory response to infection.
	Stroke Phenotype (Entity type)	Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to t...
	Enterocolitis Phenotype (Entity type)	An inflammation of the colon and small intestine. However, most conditions are either categorized as...
	Atherosclerosis Phenotype (Entity type)	A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls ...

Colitis

Phenotype (Entity type)

Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the ...

Hypertension

Phenotype (Entity type)

The presence of chronic increased pressure in the systemic arterial system.

Abdominal aortic aneurysm

Phenotype (Entity type)

An abnormal localized widening (dilatation) of the abdominal aorta.

Peripheral arterial stenosis

Phenotype (Entity type)

Narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quan...

Sepsis

Phenotype (Entity type)

Systemic inflammatory response to infection.

Stroke

Phenotype (Entity type)

Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to t...

Enterocolitis

Phenotype (Entity type)

An inflammation of the colon and small intestine. However, most conditions are either categorized as...

Atherosclerosis

Phenotype (Entity type)

A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls ...

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CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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