Synonyms:CD305, ENTREZ:3903, HGNC:6477, LAIR-1, LAIR1, MIM:602992, NM_001289023, NM_001289025, NM_001289026, NM_001289027, NM_002287, NM_021706, NM_021708, NP_001275952, NP_001275954, NP_001275955, NP_001275956, NP_002278, NP_068352, NR_110279, NR_110280, XM_017026803, XP_016882292, leukocyte associated immunoglobulin like receptor 1
Id:ENSG00000276053
Description:leukocyte associated immunoglobulin like receptor 1 [Source:HGNC Symbol;Acc:HGNC:6477]
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
