MMP11 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:4320, HGNC:7157, MIM:185261, MMP11, NM_005940, NP_005931, NR_133013, SL-3, ST3, STMY3, matrix metallopeptidase 11

Id:ENSG00000275365

Description:matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MMP11's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with MMP11.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MMP11.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MMP11.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MMP11.

Results found

Linked to

	Label	Description
	Obesity Phenotype (Entity type)	Accumulation of substantial excess body fat.
	Hypertension Phenotype (Entity type)	The presence of chronic increased pressure in the systemic arterial system.
	Anxiety Phenotype (Entity type)	Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses...
	Depression Phenotype (Entity type)	Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover fr...
	Osteoporosis Phenotype (Entity type)	Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural...
	Stroke Phenotype (Entity type)	Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to t...
	Dementia Phenotype (Entity type)	A loss of global cognitive ability of sufficient amount to interfere with normal social or occupatio...
	Neoplasm of the lung Phenotype (Entity type)	Tumor of the lung.
	Chronic fatigue Phenotype (Entity type)	Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for s...

Obesity

Phenotype (Entity type)

Accumulation of substantial excess body fat.

Hypertension

Phenotype (Entity type)

The presence of chronic increased pressure in the systemic arterial system.

Anxiety

Phenotype (Entity type)

Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses...

Depression

Phenotype (Entity type)

Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover fr...

Osteoporosis

Phenotype (Entity type)

Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural...

Stroke

Phenotype (Entity type)

Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to t...

Dementia

Phenotype (Entity type)

A loss of global cognitive ability of sufficient amount to interfere with normal social or occupatio...

Neoplasm of the lung

Phenotype (Entity type)

Tumor of the lung.

Chronic fatigue

Phenotype (Entity type)

Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for s...

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.