PARN (Gene)

Organism:

Homo sapiens

Synonyms:DAN, DKCB6, ENTREZ:5073, HGNC:8609, MIM:604212, NM_001134477, NM_001242992, NM_002582, NP_001127949, NP_001229921, NP_002573, PARN, PFBMFT4, XM_011522510, XM_011522511, XM_011522513, XM_011522514, XM_017023258, XM_017023259, XM_017023260, XM_024450292, XP_011520812, XP_011520813, XP_011520815, XP_011520816, XP_016878747, XP_016878748, XP_016878749, XP_024306060, XR_001751906, XR_001751907, poly(A)-specific ribonuclease

Id:ENSG00000274829

Description:poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609]

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PARN's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PARN.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PARN.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PARN.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PARN.

Results found

Linked to

	Label	Description
	Osteoporosis Phenotype (Entity type)	Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural...
	Alopecia Phenotype (Entity type)	A noncongenital process of hair loss, which may progress to partial or complete baldness.
	Hepatic failure Phenotype (Entity type)	A Phenotype
	Carious teeth Phenotype (Entity type)	Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has b...
	Periodontitis Phenotype (Entity type)	Inflammation of the periodontium.

Osteoporosis

Phenotype (Entity type)

Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural...

Alopecia

Phenotype (Entity type)

A noncongenital process of hair loss, which may progress to partial or complete baldness.

Hepatic failure

Phenotype (Entity type)

A Phenotype

Carious teeth

Phenotype (Entity type)

Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has b...

Periodontitis

Phenotype (Entity type)

Inflammation of the periodontium.

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.