GDF2 (Gene)

Organism:

Homo sapiens

Synonyms:BMP-9, BMP9, ENTREZ:2658, GDF2, HGNC:4217, HHT5, MIM:605120, NM_016204, NP_057288, growth differentiation factor 2

Omim:OMIM:605120

Id:ENSG00000263761

Hgnc:HGNC:4217

Entrez:2658

Ensembl:ENSG00000263761

Description:growth differentiation factor 2

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View GDF2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with GDF2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using GDF2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for GDF2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with GDF2.

Results found

Linked to

	Label	Description
	GSE168596 2 V 3 ADIPONECTIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 3 V 2 CISPLATIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE121425 GSE121426 LSD1 inhibition SET-2 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE164521 0 V 1 NITRIC OXIDE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 pyridoxine 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE150055 melphalan cardiac muscle cell 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 0 V 1 AZACITIDINE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE255432 4 V 3 IMEGLIMIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE150055 0 V 2 MELPHALAN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 pyridoxine 0 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE168596 2 V 3 ADIPONECTIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 3 V 2 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE121425 GSE121426 LSD1 inhibition SET-2 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE164521 0 V 1 NITRIC OXIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 pyridoxine 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE150055 melphalan cardiac muscle cell 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 0 V 1 AZACITIDINE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE255432 4 V 3 IMEGLIMIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE150055 0 V 2 MELPHALAN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 pyridoxine 0 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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