TDO2 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:6999, HGNC:11708, HYPTRP, MIM:191070, NM_005651, NP_005642, TDO, TDO2, TO, TPH2, TRPO, tryptophan 2, 3-dioxygenase

Id:ENSG00000262635

Description:tryptophan 2,3-dioxygenase [Source:HGNC Symbol;Acc:HGNC:11708]

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TDO2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TDO2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TDO2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TDO2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TDO2.

Results found

Linked to

	Label	Description
	Depression Phenotype (Entity type)	Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover fr...
	Chronic kidney disease Phenotype (Entity type)	Functional anomaly of the kidney persisting for at least three months.
	Nephropathy Phenotype (Entity type)	A nonspecific term referring to disease or damage of the kidneys.

Depression

Phenotype (Entity type)

Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover fr...

Chronic kidney disease

Phenotype (Entity type)

Functional anomaly of the kidney persisting for at least three months.

Nephropathy

Phenotype (Entity type)

A nonspecific term referring to disease or damage of the kidneys.

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Community

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.