Synonyms:ENTREZ:3135, HGNC:4964, HLA-G, MHC-G, MIM:142871, NM_001363567, NM_001384280, NM_001384290, NM_002127, NP_001350496, NP_001371209, NP_001371219, NP_002118, XM_017010817, XM_017010818, XM_024446420, XP_016866306, XP_016866307, XP_024302188, major histocompatibility complex, class I, G
Id:ENSG00000233095
Description:major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964]
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
