SKIC2 (Gene)

Organism:

Homo sapiens

Synonyms:170A, DDX13, ENTREZ:6499, HGNC:10898, HLP, MIM:600478, NM_006929, NP_008860, SKI2, SKI2W, SKIV2, SKIV2L, SKIV2L1, Ski2 like RNA helicase, THES2, XM_011514815, XP_011513117, XR_001743586, XR_926301

Id:ENSG00000225737

Description:SKI2 subunit of superkiller complex [Source:HGNC Symbol;Acc:HGNC:10898]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SKIC2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SKIC2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SKIC2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SKIC2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SKIC2.

Results found

Linked to

	Label	Description
	Glaucoma Phenotype (Entity type)	Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usual...
	Small for gestational age Phenotype (Entity type)	Smaller than normal size according to sex and gestational age related norms, defined as a weight bel...
	Colitis Phenotype (Entity type)	Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the ...

Glaucoma

Phenotype (Entity type)

Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usual...

Small for gestational age

Phenotype (Entity type)

Smaller than normal size according to sex and gestational age related norms, defined as a weight bel...

Colitis

Phenotype (Entity type)

Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the ...

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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