CFB (Gene)

Organism:

Homo sapiens

Synonyms:AHUS4, ARMD14, BF, BFD, CFAB, CFB, CFBD, ENTREZ:629, FB, FBI12, GBG, H2-Bf, HGNC:1037, MIM:138470, NM_001710, NP_001701, PBF2, complement factor B

Id:ENSG00000204359

Description:complement factor B [Source:HGNC Symbol;Acc:HGNC:1037]

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CFB's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CFB.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CFB.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CFB.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CFB.

Results found

Linked to

	Label	Description
	Hypertension Phenotype (Entity type)	The presence of chronic increased pressure in the systemic arterial system.
	Meningitis Phenotype (Entity type)	Inflammation of the meninges.
	Acute kidney injury Phenotype (Entity type)	Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum crea...
	CFB associations Collection (Entity type)	Associations for CFB_associations

Hypertension

Phenotype (Entity type)

The presence of chronic increased pressure in the systemic arterial system.

Meningitis

Phenotype (Entity type)

Inflammation of the meninges.

Acute kidney injury

Phenotype (Entity type)

Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum crea...

CFB associations

Collection (Entity type)

Associations for CFB_associations

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.