SPANXC (Gene)

Organism:

Homo sapiens

Synonyms:CT11.3, CTp11, ENTREZ:64663, HGNC:14331, MIM:300330, NM_022661, NP_073152, SPANX family member C, SPANX-C, SPANX-E, SPANXC, SPANXE

Id:ENSG00000198573

Entrez:64663

Ensembl:ENSG00000198573

Description:SPANX family member C

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SPANXC's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SPANXC.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SPANXC.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SPANXC.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SPANXC.

Results found

Linked to

	Label	Description
	GSE216043 cisplatin 7 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE144843 GSE144844 SMARCA2 SMARCA4 knockdown 5 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE221329 ERK BRAF inhibition thyroid gland 1 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE199107 tryptophan 4 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE149768 hypoxanthine 3 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE179235 MEK NRAS inhibition 0 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE101754 FXR1 knockdown NCI-H358 1 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE224082 demethylase inhibition 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE101754 FXR1 knockdown NCI-H358 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE230865 EYA2 knockdown 3 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE216043 cisplatin 7 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE144843 GSE144844 SMARCA2 SMARCA4 knockdown 5 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE221329 ERK BRAF inhibition thyroid gland 1 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE199107 tryptophan 4 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE149768 hypoxanthine 3 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE179235 MEK NRAS inhibition 0 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE101754 FXR1 knockdown NCI-H358 1 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE224082 demethylase inhibition 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE101754 FXR1 knockdown NCI-H358 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE230865 EYA2 knockdown 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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