SPPL2C (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:162540, HGNC:28902, IMP5, MIM:608284, NM_175882, NP_787078, SPPL2C, signal peptide peptidase like 2C

Id:ENSG00000185294

Entrez:162540

Ensembl:ENSG00000185294

Description:signal peptide peptidase like 2C

Enables protein homodimerization activity. Predicted to be involved in membrane protein proteolysis. Located in endoplasmic reticulum membrane. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SPPL2C's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SPPL2C.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SPPL2C.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SPPL2C.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SPPL2C.

Results found

Linked to

	Label	Description
	GSE210655 3 V 0 CISPLATIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE182180 1 V 2 SECRETIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	TTBK2 IDG kinase ARCHS4 coexpression Gene Set (Entity type)	A Gene Set from IDG
	DYRK1B IDG kinase ARCHS4 coexpression Gene Set (Entity type)	A Gene Set from IDG
	TESK1 IDG kinase ARCHS4 coexpression Gene Set (Entity type)	A Gene Set from IDG
	GPR137 IDG GPCR ARCHS4 coexpression Gene Set (Entity type)	A Gene Set from IDG
	GTEx Brain 20-29 vs 40-49 Down Gene Set (Entity type)	A Gene Set from GTEx
	GTEx Pituitary 20-29 vs 30-39 Up Gene Set (Entity type)	A Gene Set from GTEx
	GSE206959 reserpine 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 3 V 5 CISPLATIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS

GSE210655 3 V 0 CISPLATIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE182180 1 V 2 SECRETIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

TTBK2 IDG kinase ARCHS4 coexpression

Gene Set (Entity type)

A Gene Set from IDG

DYRK1B IDG kinase ARCHS4 coexpression

Gene Set (Entity type)

A Gene Set from IDG

TESK1 IDG kinase ARCHS4 coexpression

Gene Set (Entity type)

A Gene Set from IDG

GPR137 IDG GPCR ARCHS4 coexpression

Gene Set (Entity type)

A Gene Set from IDG

GTEx Brain 20-29 vs 40-49 Down

Gene Set (Entity type)

A Gene Set from GTEx

GTEx Pituitary 20-29 vs 30-39 Up

Gene Set (Entity type)

A Gene Set from GTEx

GSE206959 reserpine 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 3 V 5 CISPLATIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.