SLC8A1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:6546, HGNC:11068, MIM:182305, NCX1, NM_001112800, NM_001112801, NM_001112802, NM_001252624, NM_001351483, NM_001351484, NM_001351485, NM_001351486, NM_001351487, NM_001351488, NM_001351489, NM_001351490, NM_001351491, NM_001351492, NM_001351493, NM_001351494, NM_001372263, NM_001394103, NM_001394104, NM_001394105, NM_001394106, NM_001394107, NM_021097, NP_001106271, NP_001106272, NP_001106273, NP_001239553, NP_001338412, NP_001338413, NP_001338414, NP_001338415, NP_001338416, NP_001338417, NP_001338418, NP_001338419, NP_001338420, NP_001338421, NP_001338422, NP_001338423, NP_001359192, NP_001381032, NP_001381033, NP_001381034, NP_001381035, NP_001381036, NP_066920, SLC8A1, XM_006712082, XM_006712083, XM_006712084, XM_006712085, XM_011533050, XM_011533054, XM_011533055, XM_011533056, XM_011533058, XM_017004745, XM_017004746, XM_017004749, XM_017004750, XM_017004751, XM_017004752, XM_017004753, XM_017004755, XM_017004764, XP_006712145, XP_006712146, XP_006712147, XP_006712148, XP_011531352, XP_011531356, XP_011531357, XP_011531358, XP_011531360, XP_016860234, XP_016860235, XP_016860238, XP_016860239, XP_016860240, XP_016860241, XP_016860242, XP_016860244, XP_016860253, solute carrier family 8 member A1

Omim:OMIM:182305

Nci:C118227

Id:ENSG00000183023

Hgnc:HGNC:11068

Entrez:6546

Ensembl:ENSG00000183023

Description:solute carrier family 8 member A1

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SLC8A1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SLC8A1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SLC8A1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SLC8A1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SLC8A1.

Results found

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	GSE146982 metformin 4 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS