Synonyms:BAIAP2, BAP2, BAR/IMD domain containing adaptor protein 2, ENTREZ:10458, FLAF3, HGNC:947, IRSP53, MIM:605475, NM_001144888, NM_001385127, NM_001385128, NM_001385129, NM_001385130, NM_001385131, NM_001385132, NM_001385133, NM_001385134, NM_001385135, NM_001385136, NM_001385137, NM_001385138, NM_001385139, NM_001385140, NM_001385141, NM_001385144, NM_001385145, NM_001385146, NM_001385147, NM_001385148, NM_001385149, NM_001385150, NM_001385151, NM_001385152, NM_001385153, NM_001385154, NM_001385155, NM_001385156, NM_001385157, NM_001385158, NM_001385159, NM_006340, NM_017450, NM_017451, NP_001138360, NP_001372056, NP_001372057, NP_001372058, NP_001372059, NP_001372060, NP_001372061, NP_001372062, NP_001372063, NP_001372064, NP_001372065, NP_001372066, NP_001372067, NP_001372068, NP_001372069, NP_001372070, NP_001372073, NP_001372074, NP_001372075, NP_001372076, NP_001372077, NP_001372078, NP_001372079, NP_001372080, NP_001372081, NP_001372082, NP_001372083, NP_001372084, NP_001372085, NP_001372086, NP_001372087, NP_001372088, NP_006331, NP_059344, NP_059345, NR_169574, NR_169575, NR_169576, NR_169577, NR_169578, NR_169579, NR_169580, WAML, XM_011524193, XM_011524194, XM_011524195, XM_011524196, XM_017024017, XM_017024018, XM_017024019, XM_024450534, XM_024450535, XP_011522495, XP_011522496, XP_011522497, XP_011522498, XP_016879506, XP_016879507, XP_016879508, XP_024306302, XP_024306303
Omim:OMIM:605475
Id:ENSG00000175866
Hgnc:HGNC:947
Description:BAR/IMD domain containing adaptor protein 2
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
