UMOD (Gene)

Organism:

Homo sapiens

Synonyms:ADMCKD2, ADTKD1, ENTREZ:7369, FJHN, HGNC:12559, HNFJ, HNFJ1, MCKD2, MIM:191845, NM_001008389, NM_001278614, NM_001378232, NM_001378233, NM_001378234, NM_001378235, NM_001378237, NM_003361, NP_001008390, NP_001265543, NP_001365161, NP_001365162, NP_001365163, NP_001365164, NP_001365166, NP_003352, NR_165456, THGP, THP, UMOD, XM_011545935, XM_011545936, XM_011545937, XM_011545938, XM_024450433, XP_011544237, XP_011544238, XP_011544239, XP_011544240, XP_024306201, uromodulin

Omim:OMIM:191845

Id:ENSG00000169344

Hgnc:HGNC:12559

Entrez:7369

Ensembl:ENSG00000169344

Description:uromodulin

The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View UMOD's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with UMOD.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using UMOD.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for UMOD.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with UMOD.

Results found

Linked to

	Label	Description
	GSE264621 1 V 6 SECRETIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 1 V 6 CISPLATIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE152246 dihydrotestosterone 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE157960 2 V 3 PROGESTERONE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE152246 0 V 1 DIHYDROTESTOSTERONE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE264621 1 V 3 SECRETIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	G84452RH Gene Set (Entity type)	A Gene Set from GlyGen
	G48414YA Gene Set (Entity type)	A Gene Set from GlyGen
	G64527OM Gene Set (Entity type)	A Gene Set from GlyGen
	G39188ZX Gene Set (Entity type)	A Gene Set from GlyGen

GSE264621 1 V 6 SECRETIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 1 V 6 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE152246 dihydrotestosterone 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE157960 2 V 3 PROGESTERONE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE152246 0 V 1 DIHYDROTESTOSTERONE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE264621 1 V 3 SECRETIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

G84452RH

Gene Set (Entity type)

A Gene Set from GlyGen

G48414YA

Gene Set (Entity type)

A Gene Set from GlyGen

G64527OM

Gene Set (Entity type)

A Gene Set from GlyGen

G39188ZX

Gene Set (Entity type)

A Gene Set from GlyGen

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.