DENND2B (Gene)

Organism:

Homo sapiens

Gene:

TARGET ID 16277

Synonyms:DENN domain containing 2B, DENND2B, ENTREZ:6764, HGNC:11350, HTS1, MIM:140750, NM_001376495, NM_001376496, NM_001376497, NM_001376498, NM_001376499, NM_001376500, NM_001376501, NM_001376502, NM_001376503, NM_001376504, NM_001376505, NM_001376506, NM_005418, NM_139157, NM_213618, NP_001363424, NP_001363425, NP_001363426, NP_001363427, NP_001363428, NP_001363429, NP_001363430, NP_001363431, NP_001363432, NP_001363433, NP_001363434, NP_001363435, NP_005409, NP_631896, NP_998783, NR_164814, NR_164815, NR_164816, NR_164817, NR_164818, NR_164819, NR_164820, NR_164821, NR_164822, ST5, XM_005253077, XM_011520309, XM_011520320, XM_011520321, XM_011520322, XM_011520324, XM_011520329, XP_005253134, XP_011518611, XP_011518622, XP_011518623, XP_011518624, XP_011518626, XP_011518631, XR_001747941, XR_001747942, XR_001747943, XR_002957159, XR_002957160, XR_002957161, XR_002957162, XR_002957163, XR_002957164, XR_002957165, XR_002957166, XR_002957167, XR_002957168, XR_002957169, XR_002957170, XR_002957171, XR_002957172, XR_002957173, XR_002957174, XR_002957175, XR_002957176, XR_002957177, XR_002957178, XR_002957179, XR_002957180, XR_002957181, XR_002957182, XR_002957183, XR_002957184, XR_002957185, XR_002957186, XR_002957187, XR_002957188, XR_930887, p126

Id:ENSG00000166444

Entrez:6764

Ensembl:ENSG00000166444

Description:DENN domain containing 2B

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

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Playbook Workflow Builder: Gene-Centric Workflow

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CFDE Gene-Centric Appyter

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DENND2B.

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Playbook Workflow Builder

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Results found

Linked to

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	GSE225869 1 V 0 TEMOZOLOMIDE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE216273,GSE216292 14 V 6 PALBOCICLIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE226249 pirfenidone HL 0 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE216273 GSE216292 palbociclib 14 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE101239 5 V 6 VALPROIC ACID MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE48812 sulforaphane 4 v 10 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE134191 3 V 1 METFORMIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE109285 3 V 2 GLUCAGON MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876,GSE147877 2 V 7 ENZALUTAMIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS