PF4 (Gene)

Organism:

Homo sapiens

Synonyms:CXCL4, ENTREZ:5196, HGNC:8861, MIM:173460, NM_001363352, NM_002619, NP_001350281, NP_002610, PF-4, PF4, SCYB4, platelet factor 4

Omim:OMIM:173460

Id:ENSG00000163737

Hgnc:HGNC:8861

Entrez:5196

Ensembl:ENSG00000163737

Description:platelet factor 4

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PF4's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PF4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PF4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PF4.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PF4.

Results found

Linked to

	Label	Description
	GSE165548 gemcitabine 2 v 5 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE217115 3 V 5 ALECTINIB MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE143782 calcitriol 7 v 11 human dn Gene Set (Entity type)	A Gene Set from LINCS
	T62-Spleen Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE171837 3 V 1 BORTEZOMIB MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE165548 2 V 5 GEMCITABINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE179235 MEK NRAS inhibition 2 v 6 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE179235 MEK NRAS inhibition 5 v 6 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE186226 KD knockdown T24 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE216043 11 V 9 CISPLATIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE165548 gemcitabine 2 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE217115 3 V 5 ALECTINIB MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE143782 calcitriol 7 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

T62-Spleen Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE171837 3 V 1 BORTEZOMIB MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE165548 2 V 5 GEMCITABINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE179235 MEK NRAS inhibition 2 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE179235 MEK NRAS inhibition 5 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE186226 KD knockdown T24 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE216043 11 V 9 CISPLATIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.