KLHDC8A (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:55220, HGNC:25573, KLHDC8A, MIM:614503, NM_001271863, NM_001271864, NM_001271865, NM_018203, NP_001258792, NP_001258793, NP_001258794, NP_060673, XM_024448121, XP_024303889, kelch domain containing 8A

Omim:OMIM:614503

Id:ENSG00000162873

Hgnc:HGNC:25573

Entrez:55220

Ensembl:ENSG00000162873

Description:kelch domain containing 8A

This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View KLHDC8A's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with KLHDC8A.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using KLHDC8A.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for KLHDC8A.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with KLHDC8A.

Results found

Linked to

	Label	Description
	GSE102505 5 V 0 TUNICAMYCIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE74251 decitabine MCF-7 0 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE217115 3 V 5 ALECTINIB MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE165960 MEK inhibition 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE184210 0 V 1 GLUCAGON MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE216273,GSE216292 14 V 1 PALBOCICLIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE67266 7 V 3 ETOPOSIDE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE166315 1 V 0 DOCETAXEL MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE154074 5 V 0 BLEOMYCIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE176366 vincristine 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE102505 5 V 0 TUNICAMYCIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE74251 decitabine MCF-7 0 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE217115 3 V 5 ALECTINIB MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE165960 MEK inhibition 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE184210 0 V 1 GLUCAGON MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE216273,GSE216292 14 V 1 PALBOCICLIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE67266 7 V 3 ETOPOSIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE166315 1 V 0 DOCETAXEL MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE154074 5 V 0 BLEOMYCIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE176366 vincristine 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.