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WNT4 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:54361, HGNC:12783, MIM:603490, NM_030761, NP_110388, SERKAL, WNT-4, WNT4, Wnt family member 4, XM_011541597, XM_011541598, XM_011541599, XP_011539899, XP_011539900, XP_011539901
Id:ENSG00000162552
Entrez:54361
Ensembl:ENSG00000162552
Description:Wnt family member 4
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View WNT4's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with WNT4.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using WNT4.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for WNT4.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with WNT4.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE135514 8 V 7 DASATINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE131887 5 V 2 DOXYCYCLINE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE216988 GSE216989 decitabine 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE217115 3 V 5 ALECTINIB MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE184210 0 V 1 GLUCAGON MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 8 v 12 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE57871 vorinostat HCT 116 8 v 12 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE142210 4 V 7 PANOBINOSTAT HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE164529 0 V 2 TAMOXIFEN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE164521 0 V 1 NITRIC OXIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE135514 8 V 7 DASATINIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE131887 5 V 2 DOXYCYCLINE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE216988 GSE216989 decitabine 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE217115 3 V 5 ALECTINIB MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE184210 0 V 1 GLUCAGON MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 8 v 12 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE57871 vorinostat HCT 116 8 v 12 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE142210 4 V 7 PANOBINOSTAT HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE164529 0 V 2 TAMOXIFEN HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE164521 0 V 1 NITRIC OXIDE MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.