RNF111 (Gene)

Organism:

Homo sapiens

Synonyms:ARK, ENTREZ:54778, HGNC:17384, MIM:605840, NM_001270528, NM_001270529, NM_001270530, NM_001330331, NM_017610, NP_001257457, NP_001257458, NP_001257459, NP_001317260, NP_060080, RNF111, XM_006720575, XM_006720579, XM_011521694, XM_011521696, XM_011521697, XM_011521699, XM_017022336, XM_017022337, XM_017022338, XM_017022339, XM_017022340, XM_017022341, XM_017022342, XM_017022343, XP_006720638, XP_006720642, XP_011519996, XP_011519998, XP_011519999, XP_011520001, XP_016877825, XP_016877826, XP_016877827, XP_016877828, XP_016877829, XP_016877830, XP_016877831, XP_016877832, hRNF111, ring finger protein 111

Omim:OMIM:605840

Id:d963a628-1f52-56c8-9c44-0298f35a2787

Hgnc:HGNC:17384

Entrez:54778

Ensembl:ENSG00000157450

Description:ring finger protein 111

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View RNF111's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

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CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using RNF111.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for RNF111.

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Playbook Workflow Builder

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Results found

Linked to

	Label	Description
	GSE145990 1 V 0 IBRUTINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE148200 0 V 2 GEMCITABINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE116810 5 V 1 SELINEXOR HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE93156 idelalisib B cell 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE225869 3 V 0 TEMOZOLOMIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE171177,GSE171181 1 V 0 E7107 HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE197555 trametinib A-549 NCI-H460 1 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE173116 GSE173118 ML-7 8 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	T62-Spleen Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE93156 1 V 0 IDELALISIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE145990 1 V 0 IBRUTINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE148200 0 V 2 GEMCITABINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE116810 5 V 1 SELINEXOR HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE93156 idelalisib B cell 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE225869 3 V 0 TEMOZOLOMIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE171177,GSE171181 1 V 0 E7107 HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE197555 trametinib A-549 NCI-H460 1 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE173116 GSE173118 ML-7 8 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

T62-Spleen Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE93156 1 V 0 IDELALISIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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Consortium

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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