CAST (Gene)

Organism:

Homo sapiens

Synonyms:BS-17, CAST, ENTREZ:831, HGNC:1515, MIM:114090, NM_001042440, NM_001042441, NM_001042442, NM_001042443, NM_001042444, NM_001042445, NM_001042446, NM_001190442, NM_001284212, NM_001284213, NM_001330626, NM_001330627, NM_001330628, NM_001330629, NM_001330630, NM_001330631, NM_001330632, NM_001330633, NM_001330634, NM_001375317, NM_001750, NM_173060, NM_173061, NM_173062, NM_173063, NP_001035905, NP_001035906, NP_001035907, NP_001035908, NP_001035909, NP_001035910, NP_001035911, NP_001177371, NP_001271141, NP_001271142, NP_001317555, NP_001317556, NP_001317557, NP_001317558, NP_001317559, NP_001317560, NP_001317561, NP_001317562, NP_001317563, NP_001362246, NP_001741, NP_775083, NR_033798, NR_104285, PLACK, calpastatin

Id:ENSG00000153113

Description:calpastatin [Source:HGNC Symbol;Acc:HGNC:1515]

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CAST's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CAST.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CAST.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CAST.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CAST.

Results found

Linked to

	Label	Description
	L1000 LINCS DCIC KDB009 HEPG2 96H A20 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the L1000 Phase1 project
	L1000 LINCS DCIC KDB009 VCAP 120H A20 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the L1000 Phase1 project
	L1000 LINCS DCIC 2021 KDB009 VCAP 120H M02 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the LINCS 2021 project
	L1000 LINCS DCIC 2021 KDB009 HEPG2 96H A20 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the LINCS 2021 project
	L1000 LINCS DCIC 2021 KDB009 PC3 96H E18 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the LINCS 2021 project
	L1000 LINCS DCIC 2021 KDB009 A375 96H E18 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the LINCS 2021 project
	L1000 LINCS DCIC KDB009 HEPG2 96H E18 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the L1000 Phase1 project
	L1000 LINCS DCIC 2021 KDB009 PC3 144H E18 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the LINCS 2021 project
	L1000 LINCS DCIC KDB009 VCAP 120H E18 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the L1000 Phase1 project
	L1000 LINCS DCIC 2021 KDB009 NPC 96H E18 CAST Biosample (Entity type)	A biosample from LINCS produced as part of the LINCS 2021 project

L1000 LINCS DCIC KDB009 HEPG2 96H A20 CAST

Biosample (Entity type)

A biosample from LINCS produced as part of the L1000 Phase1 project

L1000 LINCS DCIC KDB009 VCAP 120H A20 CAST

Biosample (Entity type)

A biosample from LINCS produced as part of the L1000 Phase1 project

L1000 LINCS DCIC 2021 KDB009 VCAP 120H M02 CAST

Biosample (Entity type)