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DCLRE1C (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:A-SCID, DCLRE1C, DCLREC1C, DNA cross-link repair 1C, ENTREZ:64421, HGNC:17642, MIM:605988, NM_001033855, NM_001033857, NM_001033858, NM_001289076, NM_001289077, NM_001289078, NM_001289079, NM_001350965, NM_001350966, NM_001350967, NM_022487, NP_001029027, NP_001029029, NP_001029030, NP_001276005, NP_001276006, NP_001276007, NP_001276008, NP_001337894, NP_001337895, NP_001337896, NP_071932, NR_110297, NR_146960, NR_146961, NR_146962, RS-SCID, SCIDA, SNM1C, XM_006717491, XM_011519616, XM_011519617, XM_011519619, XM_011519620, XM_011519621, XM_017016557, XM_017016558, XM_024448134, XM_024448135, XP_006717554, XP_011517918, XP_011517919, XP_011517921, XP_011517922, XP_011517923, XP_016872046, XP_016872047, XP_024303902, XP_024303903, XR_001747185, XR_001747187, XR_930515
Omim:OMIM:605988
Id:ENSG00000152457
Hgnc:HGNC:17642
Entrez:64421
Ensembl:ENSG00000152457
Description:DNA cross-link repair 1C
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DCLRE1C's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DCLRE1C.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DCLRE1C.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DCLRE1C.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DCLRE1C.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE195663 cisplatin 7 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE102757 1 V 0 PANOBINOSTAT MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE229973 3 V 2 CISPLATIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE159678 4 V 2 CHLOROQUINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE213588 trametinib NF1 8 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE142210 3 V 5 PANOBINOSTAT HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115395 2 V 4 ENZALUTAMIDE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE195663 7 V 1 CISPLATIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE213588 8 V 11 TRAMETINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE182680,GSE182683 10 V 4 DEXAMETHASONE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE195663 cisplatin 7 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE102757 1 V 0 PANOBINOSTAT MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE229973 3 V 2 CISPLATIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE159678 4 V 2 CHLOROQUINE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213588 trametinib NF1 8 v 11 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE142210 3 V 5 PANOBINOSTAT HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115395 2 V 4 ENZALUTAMIDE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE195663 7 V 1 CISPLATIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213588 8 V 11 TRAMETINIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE182680,GSE182683 10 V 4 DEXAMETHASONE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.