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G6PC2 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:57818, G6PC2, HGNC:28906, IGRP, MIM:608058, NM_001081686, NM_021176, NP_001075155, NP_066999, XM_011511564, XM_011511565, XP_011509866, XP_011509867, glucose-6-phosphatase catalytic subunit 2
Omim:OMIM:608058
Id:ENSG00000152254
Hgnc:HGNC:28906
Entrez:57818
Ensembl:ENSG00000152254
Description:glucose-6-phosphatase catalytic subunit 2
This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View G6PC2's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with G6PC2.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using G6PC2.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for G6PC2.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with G6PC2.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE109285 3 V 2 GLUCAGON MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE128240 0 V 1 CYCLOPHOSPHAMIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE189653,GSE203344 5 V 3 FLUOXETINE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE142210 3 V 5 PANOBINOSTAT HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE56010 adenosine 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE155695,GSE155696 1 V 0 ACETAMINOPHEN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE67266 7 V 3 ETOPOSIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE261563 CX-5461 0 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE192710 ZIC2 ZNF423 inhibition stem cell 4 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE109285 5 V 2 GLUCAGON MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE109285 3 V 2 GLUCAGON MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE128240 0 V 1 CYCLOPHOSPHAMIDE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE189653,GSE203344 5 V 3 FLUOXETINE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE142210 3 V 5 PANOBINOSTAT HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE56010 adenosine 4 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE155695,GSE155696 1 V 0 ACETAMINOPHEN MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE67266 7 V 3 ETOPOSIDE MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE261563 CX-5461 0 v 8 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE192710 ZIC2 ZNF423 inhibition stem cell 4 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE109285 5 V 2 GLUCAGON MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.