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DET1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:DET1 partner of COP1 E3 ubiquitin ligase, DET1, ENTREZ:55070, HGNC:25477, MIM:608727, NM_001144074, NM_001321594, NM_001321596, NM_017996, NP_001137546, NP_001308523, NP_001308525, NP_060466, NR_026645, NR_135739, NR_135740, NR_135741, NR_135742, NR_135743, NR_135744
Omim:OMIM:608727
Id:ENSG00000140543
Hgnc:HGNC:25477
Entrez:55070
Ensembl:ENSG00000140543
Description:DET1 partner of COP1 E3 ubiquitin ligase
Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DET1's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DET1.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DET1.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DET1.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DET1.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE195559 NOTCH1 knockout endothelial cell cardiac muscle cell stem cell 2 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77108 8 V 7 SAHA HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE181517 0 V 1 DOXORUBICIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE206931 WDR5 inhibition WIN 3 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE74490 0 V 1 TRIPTOLIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE169152 5 V 7 IBRUTINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE119345 0 V 3 BEXAROTENE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE229070,GSE229071 0 V 2 SOTORASIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE94849 1 V 2 PINOMETOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE131649 6 V 3 HEMIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE195559 NOTCH1 knockout endothelial cell cardiac muscle cell stem cell 2 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77108 8 V 7 SAHA HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE181517 0 V 1 DOXORUBICIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE206931 WDR5 inhibition WIN 3 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE74490 0 V 1 TRIPTOLIDE MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE169152 5 V 7 IBRUTINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE119345 0 V 3 BEXAROTENE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE229070,GSE229071 0 V 2 SOTORASIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE94849 1 V 2 PINOMETOSTAT HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE131649 6 V 3 HEMIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.