Synonyms:ENTREZ:2120, ETS variant transcription factor 6, ETV6, HGNC:3495, MIM:600618, NM_001987, NP_001978, TEL, TEL/ABL, THC5, XM_011520607, XM_011520608, XM_011520609, XM_011520611, XM_011520612, XM_017018990, XM_017018991, XP_011518909, XP_011518910, XP_011518911, XP_011518913, XP_011518914, XP_016874479, XP_016874480
Omim:OMIM:600618
Id:b03882e0-4666-567d-a375-47d75b93d753
Hgnc:HGNC:3495
Description:ETS variant transcription factor 6
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]