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CYP2C8 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CPC8, CYP2C8, CYP2C8DM, CYPIIC8, ENTREZ:1558, HGNC:2622, MIM:601129, MP-12/MP-20, NM_000770, NM_001198853, NM_001198854, NM_001198855, NM_030878, NP_000761, NP_001185782, NP_001185783, NP_001185784, cytochrome P450 family 2 subfamily C member 8
Omim:OMIM:601129
Id:ENSG00000138115
Hgnc:HGNC:2622
Entrez:1558
Ensembl:ENSG00000138115
Description:cytochrome P450 family 2 subfamily C member 8
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP2C8's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP2C8.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP2C8.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP2C8.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP2C8.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE114492 GSE153671 KMT2D inhibition 6 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE203362 0 V 1 ENZALUTAMIDE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE216988 GSE216989 decitabine 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE192860 0 V 1 TRIFLUOPERAZINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE80098 GSE80366 progesterone 0 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE151612 0 V 2 PRACINOSTAT HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE239844 crizotinib 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE143782 calcitriol 6 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE183741 GSE183806 POU2F2 POU2AF1 knockdown UtE-iPS-1 2 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE193258,GSE193259 2 V 12 OSIMERTINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE114492 GSE153671 KMT2D inhibition 6 v 8 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE203362 0 V 1 ENZALUTAMIDE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE216988 GSE216989 decitabine 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE192860 0 V 1 TRIFLUOPERAZINE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE80098 GSE80366 progesterone 0 v 8 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE151612 0 V 2 PRACINOSTAT HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239844 crizotinib 7 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE143782 calcitriol 6 v 5 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE183741 GSE183806 POU2F2 POU2AF1 knockdown UtE-iPS-1 2 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE193258,GSE193259 2 V 12 OSIMERTINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.