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CFC1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CFC1, CFC1B, CRYPTIC, DTGA2, ENTREZ:55997, HGNC:18292, HTX2, MIM:605194, NM_001270420, NM_001270421, NM_032545, NP_001257349, NP_001257350, NP_115934, XM_011511486, XP_011509788, cripto, FRL-1, cryptic family 1
Omim:OMIM:605194
Id:ENSG00000136698
Hgnc:HGNC:18292
Entrez:55997
Ensembl:ENSG00000136698
Description:cryptic, EGF-CFC family member 1
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CFC1's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CFC1.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CFC1.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CFC1.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CFC1.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE108464 AZ-628 11 v 12 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE176008 8 V 1 AZACITIDINE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE239688 canagliflozin 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE157960 0 V 3 PROGESTERONE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE225901 dexamethasone 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE239688 4 V 3 CANAGLIFLOZIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE151083 enzalutamide 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE239688 canagliflozin 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE151083 0 V 1 ENZALUTAMIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE156761 dopamine neuron 0 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE108464 AZ-628 11 v 12 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE176008 8 V 1 AZACITIDINE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239688 canagliflozin 4 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE157960 0 V 3 PROGESTERONE MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE225901 dexamethasone 2 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239688 4 V 3 CANAGLIFLOZIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE151083 enzalutamide 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239688 canagliflozin 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE151083 0 V 1 ENZALUTAMIDE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE156761 dopamine neuron 0 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.