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CFHR4 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CFHL4, CFHR4, ENTREZ:10877, FHR-4, FHR4, HGNC:16979, MIM:605337, NM_001201550, NM_001201551, NM_006684, NP_001188479, NP_001188480, NP_006675, XM_006711129, XM_017000110, XM_017000111, XM_017000112, XM_017000113, XM_017000114, XP_006711192, XP_016855599, XP_016855600, XP_016855601, XP_016855602, XP_016855603, complement factor H related 4
Omim:OMIM:605337
Id:ENSG00000134365
Hgnc:HGNC:16979
Entrez:10877
Ensembl:ENSG00000134365
Description:complement factor H related 4
This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CFHR4's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CFHR4.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CFHR4.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CFHR4.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CFHR4.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE229973 3 V 2 CISPLATIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE100148 EZH2 inhibition 10 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE179235 MEK NRAS inhibition 2 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE179235 MEK NRAS inhibition 5 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE110709 GSK-J4 5 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE189772 GSE189773 CTB CTBp 3 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE189772 GSE189773 MHC FBXO11 inhibition CTBp 3 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE172494 nicotinamide 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE201309 matrine 1 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE224082 demethylase inhibition 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE229973 3 V 2 CISPLATIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE100148 EZH2 inhibition 10 v 5 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE179235 MEK NRAS inhibition 2 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE179235 MEK NRAS inhibition 5 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE110709 GSK-J4 5 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE189772 GSE189773 CTB CTBp 3 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE189772 GSE189773 MHC FBXO11 inhibition CTBp 3 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE172494 nicotinamide 3 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE201309 matrine 1 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE224082 demethylase inhibition 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.