CHIT1 (Gene)

Organism:

Homo sapiens

Synonyms:CHI3, CHIT, CHIT1, CHITD, ENTREZ:1118, HGNC:1936, MIM:600031, NM_001256125, NM_001270509, NM_003465, NP_001243054, NP_003456, NR_045784, NR_045785, chitinase 1

Omim:OMIM:600031

Id:ENSG00000133063

Hgnc:HGNC:1936

Entrez:1118

Ensembl:ENSG00000133063

Description:chitinase 1

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CHIT1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CHIT1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CHIT1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CHIT1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CHIT1.

Results found

Linked to

	Label	Description
	GSE164874 5 V 10 PREDNISOLONE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE114883 romidepsin T cell 0 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 7 V 5 ETOPOSIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE114883 romidepsin T cell 1 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE166536 3 V 2 DOCETAXEL MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434,GSE202438 2 V 14 TALAZOPARIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE196117 6 V 8 CLARITHROMYCIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE114883 0 V 4 ROMIDEPSIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE114883 1 V 4 ROMIDEPSIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE205674 TEPP-46 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE164874 5 V 10 PREDNISOLONE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE114883 romidepsin T cell 0 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE120612 7 V 5 ETOPOSIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE114883 romidepsin T cell 1 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE166536 3 V 2 DOCETAXEL MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434,GSE202438 2 V 14 TALAZOPARIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE196117 6 V 8 CLARITHROMYCIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE114883 0 V 4 ROMIDEPSIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE114883 1 V 4 ROMIDEPSIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE205674 TEPP-46 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.