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SLC12A5 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:DEE34, EIEE34, EIG14, ENTREZ:57468, HGNC:13818, KCC2, MIM:606726, NM_001134771, NM_020708, NP_001128243, NP_065759, SLC12A5, hKCC2, solute carrier family 12 member 5
Omim:OMIM:606726
Id:ENSG00000124140
Hgnc:HGNC:13818
Entrez:57468
Ensembl:ENSG00000124140
Description:solute carrier family 12 member 5
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SLC12A5's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SLC12A5.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SLC12A5.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SLC12A5.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SLC12A5.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE120612 etoposide leukocyte 6 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

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GSE195663 cisplatin 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE189035 inositol 2 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE100148 EZH2 inhibition 10 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE184210 0 V 1 GLUCAGON MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE95688 7 V 2 GLUTATHIONE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE150540 dipyridamole DPM HUVEC-C 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE208350 H-7 Huh-7 JHH-7 4 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE157109 TRIM8 knockdown MCF-7 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE193751 1 V 3 ORIDONIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE120612 etoposide leukocyte 6 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE195663 cisplatin 0 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE189035 inositol 2 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE100148 EZH2 inhibition 10 v 5 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE184210 0 V 1 GLUCAGON MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE95688 7 V 2 GLUTATHIONE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE150540 dipyridamole DPM HUVEC-C 1 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE208350 H-7 Huh-7 JHH-7 4 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE157109 TRIM8 knockdown MCF-7 0 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE193751 1 V 3 ORIDONIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.