Synonyms:ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3, CENTD3, DRAG1, ENTREZ:64411, HGNC:24097, MIM:606647, NM_022481, NP_071926, XM_005268497, XM_005268498, XM_005268499, XM_005268500, XM_006714792, XM_011537677, XP_005268554, XP_005268555, XP_005268556, XP_005268557, XP_006714855, XP_011535979, XR_944329
Omim:OMIM:606647
Id:ENSG00000120318
Hgnc:HGNC:24097
Description:ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]