SMG7 (Gene)

Organism:

Homo sapiens

Synonyms:C1orf16, ENTREZ:9887, EST1C, HGNC:16792, MIM:610964, NM_001174061, NM_001331007, NM_001350219, NM_001350220, NM_001350221, NM_001350222, NM_001375584, NM_001375585, NM_001394133, NM_001394134, NM_001394135, NM_001394136, NM_001394137, NM_001394138, NM_001394139, NM_001394140, NM_001394141, NM_001394142, NM_001394143, NM_001394144, NM_001394145, NM_001394146, NM_001394147, NM_014837, NM_173156, NM_201568, NM_201569, NP_001167532, NP_001317936, NP_001337148, NP_001337149, NP_001337150, NP_001337151, NP_001362513, NP_001362514, NP_001381062, NP_001381063, NP_001381064, NP_001381065, NP_001381066, NP_001381067, NP_001381068, NP_001381069, NP_001381070, NP_001381071, NP_001381072, NP_001381073, NP_001381074, NP_001381075, NP_001381076, NP_775179, NP_963862, NP_963863, SGA56M, SMG7 nonsense mediated mRNA decay factor, SMG7, XM_005245649, XM_005245653, XM_011510205, XM_011510206, XM_011510207, XM_011510208, XM_011510209, XM_011510210, XM_017002968, XM_017002969, XM_017002970, XP_005245706, XP_005245710, XP_011508507, XP_011508508, XP_011508509, XP_011508510, XP_011508511, XP_011508512, XP_016858457, XP_016858458, XP_016858459

Omim:OMIM:610964

Id:ENSG00000116698

Hgnc:HGNC:16792

Entrez:9887

Ensembl:ENSG00000116698

Description:SMG7 nonsense mediated mRNA decay factor

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SMG7's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SMG7.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SMG7.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SMG7.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SMG7.

Results found

Linked to

	Label	Description
	GSE168401 2 V 0 HARMINE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE163862 2 V 3 CISPLATIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 temozolomide LN-308 0 v 8 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 temozolomide LN-308 2 v 13 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE48812 0 V 10 SULFORAPHANE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 temozolomide LN-308 0 v 6 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE192771 2 V 0 SORAFENIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE226285 3 V 1 GLUTATHIONE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE171177,GSE171181 1 V 0 E7107 HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE233679 6 V 1 NICOTINAMIDE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE168401 2 V 0 HARMINE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE163862 2 V 3 CISPLATIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 temozolomide LN-308 0 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 temozolomide LN-308 2 v 13 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE48812 0 V 10 SULFORAPHANE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 temozolomide LN-308 0 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE192771 2 V 0 SORAFENIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE226285 3 V 1 GLUTATHIONE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE171177,GSE171181 1 V 0 E7107 HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE233679 6 V 1 NICOTINAMIDE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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