Synonyms:ENTREZ:5602, HGNC:6872, JNK3, JNK3A, MAPK10, MIM:602897, NM_001318067, NM_001318068, NM_001318069, NM_001351624, NM_001351625, NM_001363657, NM_002753, NM_138980, NM_138981, NM_138982, NP_001304996, NP_001304997, NP_001304998, NP_001338553, NP_001338554, NP_001350586, NP_002744, NP_620446, NP_620448, PRKM10, SAPK1b, XM_005263129, XM_005263130, XM_005263131, XM_005263135, XM_006714268, XM_006714269, XM_011532117, XM_011532118, XM_011532120, XM_011532121, XM_017008420, XM_017008422, XM_017008423, XM_017008427, XM_017008428, XM_017008429, XM_017008430, XM_017008432, XM_017008433, XM_017008434, XM_017008435, XM_017008436, XM_017008437, XM_017008441, XM_017008445, XM_017008447, XM_017008448, XM_017008449, XM_017008450, XM_017008451, XM_017008452, XM_017008453, XM_017008454, XM_024454139, XM_024454140, XM_024454141, XM_024454142, XM_024454143, XM_024454144, XM_024454145, XM_024454146, XM_024454147, XM_024454148, XM_024454149, XP_005263186, XP_005263187, XP_005263188, XP_005263192, XP_006714331, XP_006714332, XP_011530419, XP_011530420, XP_011530422, XP_011530423, XP_016863909, XP_016863911, XP_016863912, XP_016863916, XP_016863917, XP_016863918, XP_016863919, XP_016863921, XP_016863922, XP_016863923, XP_016863924, XP_016863925, XP_016863926, XP_016863930, XP_016863934, XP_016863936, XP_016863937, XP_016863938, XP_016863939, XP_016863940, XP_016863941, XP_016863942, XP_016863943, XP_024309907, XP_024309908, XP_024309909, XP_024309910, XP_024309911, XP_024309912, XP_024309913, XP_024309914, XP_024309915, XP_024309916, XP_024309917, XR_001741289, mitogen-activated protein kinase 10, p493F12, p54bSAPK
Omim:OMIM:602897
Id:ENSG00000109339
Hgnc:HGNC:6872
Description:mitogen-activated protein kinase 10
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
