Synonyms:CARD8, CARDINAL, DACAR, DAKAR, ENTREZ:22900, HGNC:17057, MIM:609051, NDPP, NDPP1, NM_001184900, NM_001184901, NM_001184902, NM_001184903, NM_001184904, NM_001351782, NM_001351783, NM_001351784, NM_001351786, NM_001351787, NM_001351788, NM_001351789, NM_001351790, NM_001351791, NM_001351792, NM_001365950, NM_014959, NP_001171829, NP_001171830, NP_001171831, NP_001171832, NP_001171833, NP_001338711, NP_001338712, NP_001338713, NP_001338715, NP_001338716, NP_001338717, NP_001338718, NP_001338719, NP_001338720, NP_001338721, NP_001352879, NP_055774, NR_033678, NR_033679, NR_033680, NR_147707, TUCAN, XM_006723091, XM_006723092, XM_006723093, XM_006723094, XM_006723096, XM_006723097, XM_006723098, XM_006723102, XM_006723104, XM_006723106, XM_006723107, XM_006723109, XM_006723110, XM_011526641, XM_011526643, XM_011526644, XM_011526646, XM_011526647, XM_011526648, XM_011526650, XM_017026482, XM_017026483, XM_017026484, XM_017026485, XM_017026487, XM_017026488, XM_017026492, XM_017026498, XM_017026499, XM_024451421, XM_024451422, XM_024451423, XM_024451424, XM_024451425, XP_006723154, XP_006723155, XP_006723156, XP_006723157, XP_006723159, XP_006723160, XP_006723161, XP_006723165, XP_006723167, XP_006723169, XP_006723170, XP_006723172, XP_006723173, XP_011524943, XP_011524945, XP_011524946, XP_011524948, XP_011524949, XP_011524950, XP_011524952, XP_016881971, XP_016881972, XP_016881973, XP_016881974, XP_016881976, XP_016881977, XP_016881981, XP_016881987, XP_016881988, XP_024307189, XP_024307190, XP_024307191, XP_024307192, XP_024307193, XR_001753636, XR_001753637, XR_430193, caspase recruitment domain family member 8
Omim:OMIM:609051
Id:ENSG00000105483
Hgnc:HGNC:17057
Description:caspase recruitment domain family member 8
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
