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PPM1A (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:5494, HGNC:9275, MIM:606108, NM_021003, NM_177951, NM_177952, NP_066283, NP_808820, NP_808821, PP2C-ALPHA, PP2CA, PP2Calpha, PPM1A, XM_005267779, XM_005267781, XM_011536872, XM_011536876, XM_011536877, XM_011536878, XM_011536879, XM_011536880, XM_011536881, XM_011536882, XM_011536883, XM_017021381, XM_017021382, XM_017021383, XM_017021384, XM_017021385, XM_017021386, XM_017021387, XM_024449637, XP_005267836, XP_005267838, XP_011535174, XP_011535178, XP_011535179, XP_011535180, XP_011535181, XP_011535182, XP_011535183, XP_011535184, XP_011535185, XP_016876870, XP_016876871, XP_016876872, XP_016876873, XP_016876874, XP_016876875, XP_016876876, XP_024305405, protein phosphatase, Mg2+/Mn2+ dependent 1A
Omim:OMIM:606108
Id:ENSG00000100614
Hgnc:HGNC:9275
Entrez:5494
Ensembl:ENSG00000100614
Description:protein phosphatase, Mg2+/Mn2+ dependent 1A
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PPM1A's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PPM1A.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PPM1A.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PPM1A.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PPM1A.

Results found

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    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 6 v 11 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    GSE184210 0 V 1 GLUCAGON MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239844 11 V 9 CRIZOTINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

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    A Gene Set from LINCS

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    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

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    A Gene Set from LINCS

  • Gene Set

    GSE202434,GSE202438 6 V 11 TALAZOPARIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

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    GSE201309 5 V 0 MATRINE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE153871 cytarabine U2OS 5 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
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