LRRFIP2 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:9209, HGNC:6703, HUFI-2, LRR binding FLII interacting protein 2, LRRFIP2, MIM:614043, NM_001134369, NM_001282691, NM_001348297, NM_001348298, NM_001348299, NM_001348300, NM_001348301, NM_001348302, NM_001348303, NM_001348304, NM_001348305, NM_001348306, NM_001348307, NM_001348308, NM_001348309, NM_001348310, NM_001348311, NM_006309, NM_017724, NP_001127841, NP_001269620, NP_001335226, NP_001335227, NP_001335228, NP_001335229, NP_001335230, NP_001335231, NP_001335232, NP_001335233, NP_001335234, NP_001335235, NP_001335236, NP_001335237, NP_001335238, NP_001335239, NP_001335240, NP_006300, NP_060194, NR_145514, XM_005265539, XM_005265540, XM_005265551, XM_006713385, XM_006713386, XM_006713387, XM_006713388, XM_006713389, XM_006713390, XM_006713392, XM_006713393, XM_006713394, XM_006713395, XM_006713396, XM_006713397, XM_006713400, XM_011534217, XM_011534218, XM_011534219, XM_011534222, XM_011534229, XM_017007466, XM_017007467, XM_017007469, XM_017007471, XM_017007472, XM_017007473, XM_017007476, XM_017007479, XM_017007484, XM_024453820, XM_024453821, XM_024453823, XM_024453824, XM_024453826, XP_005265596, XP_005265597, XP_005265608, XP_006713448, XP_006713449, XP_006713450, XP_006713451, XP_006713452, XP_006713453, XP_006713455, XP_006713456, XP_006713457, XP_006713458, XP_006713459, XP_006713460, XP_006713463, XP_011532519, XP_011532520, XP_011532521, XP_011532524, XP_011532531, XP_016862955, XP_016862956, XP_016862958, XP_016862960, XP_016862961, XP_016862962, XP_016862965, XP_016862968, XP_016862973, XP_024309588, XP_024309589, XP_024309591, XP_024309592, XP_024309594, XR_001740363

Omim:OMIM:614043

Id:be8853bc-0ebb-5ba9-ab91-af1531ff3a9f

Hgnc:HGNC:6703

Entrez:9209

Ensembl:ENSG00000093167

Description:LRR binding FLII interacting protein 2

The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LRRFIP2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LRRFIP2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LRRFIP2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LRRFIP2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LRRFIP2.

Results found

Linked to

	Label	Description
	GSE225869 1 V 0 TEMOZOLOMIDE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE248769 1 V 0 SORAFENIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE169356 ivermectin prostate gland 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE169356 FOXA1 inhibition prostate gland Ivermectin 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE159678 4 V 2 CHLOROQUINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE109285 3 V 2 GLUCAGON MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE108464 AZ-628 1 v 15 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE206927 PPARG knockdown endothelial cell 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876 GSE147877 enzalutamide MR42D 4 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE234647 1 V 3 REGORAFENIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS