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ATRX (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ATRX chromatin remodeler, ATRX, ENTREZ:546, HGNC:886, JMS, MIM:300032, MRX52, NM_000489, NM_138270, NM_138271, NP_000480, NP_612114, RAD54, RAD54L, XH2, XM_005262153, XM_005262154, XM_005262155, XM_005262156, XM_005262157, XM_006724666, XM_006724667, XM_006724668, XM_017029601, XM_017029602, XM_017029603, XM_017029604, XM_017029605, XM_017029606, XM_017029607, XM_017029608, XM_017029609, XM_017029610, XM_017029611, XNP, XP_005262210, XP_005262211, XP_005262212, XP_005262213, XP_005262214, XP_006724729, XP_006724730, XP_006724731, XP_016885090, XP_016885091, XP_016885092, XP_016885093, XP_016885094, XP_016885095, XP_016885096, XP_016885097, XP_016885098, XP_016885099, XP_016885100, XR_001755700, ZNF-HX
Id:ENSG00000085224
Entrez:546
Ensembl:ENSG00000085224
Description:ATRX chromatin remodeler
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ATRX's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ATRX.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ATRX.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ATRX.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ATRX.

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
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