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CBFA2T2 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CBFA2/RUNX1 partner transcriptional co-repressor 2, CBFA2T2, EHT, ENTREZ:9139, HGNC:1536, MIM:603672, MTGR1, NM_001032999, NM_001039709, NM_005093, NM_175864, NP_001028171, NP_001034798, NP_005084, XM_011529101, XM_011529102, XM_011529103, XM_011529107, XM_017028121, XM_017028122, XM_017028123, XM_017028124, XM_017028125, XP_011527403, XP_011527404, XP_011527405, XP_011527409, XP_016883610, XP_016883611, XP_016883612, XP_016883613, XP_016883614, ZMYND3, p85
Omim:OMIM:603672
Id:ENSG00000078699
Hgnc:HGNC:1536
Entrez:9139
Ensembl:ENSG00000078699
Description:CBFA2/RUNX1 partner transcriptional co-repressor 2
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CBFA2T2's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CBFA2T2.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CBFA2T2.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CBFA2T2.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CBFA2T2.

Results found

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    Gene Set (Entity type)

    A Gene Set from LINCS

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    GSE233679 12 V 0 NICOTINAMIDE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 6 v 11 human up

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    A Gene Set from LINCS

  • Gene Set

    GSE213588 trametinib NF1 8 v 11 human up

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    A Gene Set from LINCS

  • Gene Set

    GSE226249 pirfenidone HL 0 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE116810 5 V 1 SELINEXOR HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE158834 12 V 6 PALMITIC ACID HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE216043 cisplatin 7 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE114492 GSE153671 KMT2D inhibition 10 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE108464 AZ-628 11 v 12 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.