GUCA2B (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:2981, GCAP-II, GUCA2B, HGNC:4683, MIM:601271, NM_007102, NP_009033, UGN, guanylate cyclase activator 2B

Id:ENSG00000044012

Entrez:2981

Ensembl:ENSG00000044012

Description:guanylate cyclase activator 2B

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View GUCA2B's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with GUCA2B.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using GUCA2B.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for GUCA2B.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with GUCA2B.

Results found

Linked to

	Label	Description
	GSE189035 inositol 2 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 1 V 0 CISPLATIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE189035 inositol 2 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE211983 1 V 3 NICOTINE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 1 V 6 CISPLATIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE157050,GSE157051 2 V 3 METFORMIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE109140 2 V 1 VALPROIC ACID HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE162276 4 V 0 ROSIGLITAZONE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE108464 AZ-628 6 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE68156 0 V 1 DEXTRAN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS

GSE189035 inositol 2 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 1 V 0 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE189035 inositol 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE211983 1 V 3 NICOTINE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 1 V 6 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE157050,GSE157051 2 V 3 METFORMIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE109140 2 V 1 VALPROIC ACID HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE162276 4 V 0 ROSIGLITAZONE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE108464 AZ-628 6 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE68156 0 V 1 DEXTRAN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.