OTC (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:5009, HGNC:8512, MIM:300461, NM_000531, NP_000522, OCTD, OTC, OTCD, XM_017029556, XP_016885045, ornithine transcarbamylase

Omim:OMIM:300461

Id:ENSG00000036473

Hgnc:HGNC:8512

Entrez:5009

Ensembl:ENSG00000036473

Description:ornithine transcarbamylase

This nuclear gene encodes a mitochondrial matrix enzyme. The encoded protein is involved in the urea cycle which functions to detoxify ammonia into urea for excretion. Mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. [provided by RefSeq, May 2022]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View OTC's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with OTC.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using OTC.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for OTC.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with OTC.

Results found

Linked to

	Label	Description
	GSE114492 GSE153671 KMT2D inhibition 6 v 8 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE168596 2 V 3 ADIPONECTIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 3 V 2 CISPLATIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE241036 0 V 1 ETHANOL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE220520 3 V 4 ETHANOL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE158458 2 V 1 SORAFENIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE241036 0 V 3 ETHANOL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE62843,GSE64371 4 V 3 FURAN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE248858 4 V 7 TCPOBOP MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE158431 2 V 6 PIOGLITAZONE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS

GSE114492 GSE153671 KMT2D inhibition 6 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE168596 2 V 3 ADIPONECTIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 3 V 2 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE241036 0 V 1 ETHANOL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE220520 3 V 4 ETHANOL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE158458 2 V 1 SORAFENIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE241036 0 V 3 ETHANOL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE62843,GSE64371 4 V 3 FURAN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE248858 4 V 7 TCPOBOP MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE158431 2 V 6 PIOGLITAZONE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

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Community

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.