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CFLAR (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CASH, CASP8 and FADD like apoptosis regulator, CASP8AP1, CFLAR, CLARP, Casper, ENTREZ:8837, FLAME, FLAME-1, FLAME1, FLIP, HGNC:1876, I-FLICE, MIM:603599, MRIT, NM_001127183, NM_001127184, NM_001202515, NM_001202516, NM_001202517, NM_001202518, NM_001202519, NM_001308042, NM_001308043, NM_001351590, NM_001351591, NM_001351592, NM_001351593, NM_001351594, NM_003879, NP_001120655, NP_001120656, NP_001189444, NP_001189445, NP_001189446, NP_001189447, NP_001189448, NP_001294971, NP_001294972, NP_001338519, NP_001338520, NP_001338521, NP_001338522, NP_001338523, NP_003870, NR_147241, NR_147242, NR_147243, NR_147244, NR_147245, NR_147246, NR_147247, NR_147248, NR_147249, NR_147250, NR_147251, NR_147252, NR_147253, NR_147255, XM_017005189, XM_017005190, XM_017005191, XM_017005193, XM_017005195, XP_016860678, XP_016860679, XP_016860680, XP_016860682, XP_016860684, XR_001739013, XR_001739016, XR_001739017, XR_001739018, XR_002959354, XR_002959355, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP
Omim:OMIM:603599
Id:23226cec-0e96-528a-8f9c-f3273abf6116
Hgnc:HGNC:1876
Entrez:8837
Ensembl:ENSG00000003402
Description:CASP8 and FADD like apoptosis regulator
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CFLAR's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CFLAR.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CFLAR.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CFLAR.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CFLAR.

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.