KRIT1 (Gene)

Organism:

Homo sapiens

Synonyms:CAM, CCM1, ENTREZ:889, HGNC:1573, KRIT1 ankyrin repeat containing, KRIT1, MIM:604214, NM_001013406, NM_001350669, NM_001350670, NM_001350671, NM_001350672, NM_001350673, NM_001350674, NM_001350675, NM_001350676, NM_001350677, NM_001350678, NM_001350679, NM_001350680, NM_001350681, NM_001350682, NM_001350683, NM_001350684, NM_001350685, NM_001350686, NM_001350687, NM_001350688, NM_001350689, NM_001350690, NM_001350691, NM_001350692, NM_001350693, NM_001350694, NM_001350695, NM_001350696, NM_001350697, NM_004912, NM_194454, NM_194455, NM_194456, NP_001013424, NP_001337598, NP_001337599, NP_001337600, NP_001337601, NP_001337602, NP_001337603, NP_001337604, NP_001337605, NP_001337606, NP_001337607, NP_001337608, NP_001337609, NP_001337610, NP_001337611, NP_001337612, NP_001337613, NP_001337614, NP_001337615, NP_001337616, NP_001337617, NP_001337618, NP_001337619, NP_001337620, NP_001337621, NP_001337622, NP_001337623, NP_001337624, NP_001337625, NP_001337626, NP_004903, NP_919436, NP_919437, NP_919438

Id:ENSG00000001631

Entrez:889

Ensembl:ENSG00000001631

Description:KRIT1 ankyrin repeat containing

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View KRIT1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with KRIT1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using KRIT1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for KRIT1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with KRIT1.

Results found

Linked to

	Label	Description
	GSE102505 5 V 0 TUNICAMYCIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE229973 3 V 2 CISPLATIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE93156 idelalisib B cell 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE114883 0 V 5 ROMIDEPSIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE146612 2 V 0 AMIODARONE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 3 v 11 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE172458 0 V 1 CISPLATIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE172219 adenosine 2 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE93156 1 V 0 IDELALISIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE174498,GSE174500 5 V 8 ASPARAGINASE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS

GSE102505 5 V 0 TUNICAMYCIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE229973 3 V 2 CISPLATIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE93156 idelalisib B cell 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE114883 0 V 5 ROMIDEPSIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE146612 2 V 0 AMIODARONE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 3 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE172458 0 V 1 CISPLATIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE172219 adenosine 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE93156 1 V 0 IDELALISIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE174498,GSE174500 5 V 8 ASPARAGINASE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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