SNT483.ZTTL.553 (Collection)

Taxon:

Mus musculus

Taxonomy (Entity type)

Dcc Asset:

sennet c2m2 jun26.zip

Processed File (Entity type)

Dcc:

SenNet

DCC (Entity type)

Anatomy:

Heart

Anatomy (Entity type)

Persistent Id:https://doi.org/10.60586/SNT483.ZTTL.553

Has Time Series Data:0

Description:We aim to map the distribution and transcriptional heterogeneity of senescent cells in heart of aged mice using Xenium spatial transcriptomics. We use p21-Cre mice to eliminate p21high senescent cells in vivo. The heart tissue is collected from three groups of mice: young mice (6 months old), aged mice (27 months old, p21-Cre/+; LUC/+), and aged mice with eliminated senescent cells (27 months old, p21-Cre/+; DTA/+). After fixation, paraffin embedding, and sectioning, tissues are analyzed using Xenium spatial gene expression profiling and stained with hematoxylin and eosin (H&E). Spatial mapping visualizes tissue structure and the localization of senescent cells, comprehensively demonstrating how the number, characteristics, and microenvironment of senescent cells change in heart tissue.

Creation Time:2026-02-26 18:17:59.450000

Results found

Linked to

	Label	Description
	matrix.mtx.gz File (Entity type)	A 97.4 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	barcodes.tsv.gz File (Entity type)	A 1.54 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	cell boundaries.csv.gz File (Entity type)	A 98.9 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	nucleus boundaries.csv.gz File (Entity type)	A 85.3 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	cells.csv.gz File (Entity type)	A 22.0 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	features.tsv.gz File (Entity type)	A 4.25 KB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	cycle 07 grn.tiff File (Entity type)	A 4.81 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	cycle 08 red.tiff File (Entity type)	A 6.15 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	differential expression.csv File (Entity type)	A 225 KB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project
	clusters.csv File (Entity type)	A 4.91 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

matrix.mtx.gz

File (Entity type)

A 97.4 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

barcodes.tsv.gz

File (Entity type)

A 1.54 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

cell boundaries.csv.gz

File (Entity type)

A 98.9 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

nucleus boundaries.csv.gz

File (Entity type)

A 85.3 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

cells.csv.gz

File (Entity type)

A 22.0 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

features.tsv.gz

File (Entity type)

A 4.25 KB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

cycle 07 grn.tiff

File (Entity type)

A 4.81 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

cycle 08 red.tiff

File (Entity type)

A 6.15 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

differential expression.csv

File (Entity type)

A 225 KB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

clusters.csv

File (Entity type)

A 4.91 MB file from SenNet produced from OBI:0001985 as part of the TMC The Jackson Laboratory project

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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