SNT645.SXXQ.565 (Collection)

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Description:The two primary functions of the pancreas; endocrine regulation of blood glucose and exocrine production of digestive enzymes, are known to decline with age contributing to development of chronic age-related diseases. Senescent cell burden has been implicated in the reduction in function of both endocrine and exocrine compartments however characterization of pancreatic senescent cells requires additional depth and breadth in order to reproducibly identify senescent populations and define salient features. Procurement of healthy aged pancreata from humans is difficult due to the prevalence of pancreatic and metabolic disorders thereby making effective mouse models of aging critical tools for understanding normal pancreatic aging and senescent cell accumulation. Therefore we sought to characterize senescence and age-related features of the pancreas utilizing individual healthy mouse pancreata from aged (24MO C57BL/6J n=6) and young (6MO C57BL/6J n=6) mice. We utilized Visium spatial transcriptomics to characterize near whole sections of mouse. In this way we were able to profile healthy young and aged mouse pancreata while preserving spatial orientation of cells within tissue in order to identify senescence and age related features.

Creation Time:2026-02-04 19:10:50.385000