SNT264.HDBG.628 (Collection)

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Description:We aim to resolve senescence-associated gene expression at single-cell resolution across the exocrine and endocrine compartments of the human pancreas, capturing both established and co-expressed markers of senescence in a cell type-specific manner. We generate single-cell RNA sequencing (scRNA-seq) data using the 10x Genomics Chromium platform with Fixed RNA Profiling (Flex) probe-based chemistry from three anatomically and functionally distinct pancreatic fractions — acinar, ductal, and islet tissue — isolated separately from whole pancreases collected from brain dead donors across the adult lifespan. We identify and explore transcriptionally resolved cell types and states within each compartment, including exocrine populations such as acinar and ductal cells, and endocrine populations within the islets of Langerhans, enabling cross-compartment comparisons of cellular composition and gene expression heterogeneity.
Creation Time:2024-11-18 15:39:14.844000
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A 348 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

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A 519 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

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A 344 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

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A 518 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

File

A 511 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

File

A 516 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

File

A 350 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

File

A 349 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

File

A 344 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

File

A 510 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

  • File

    A 348 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 519 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 344 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 518 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 511 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 516 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 350 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 349 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 344 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project


  • File

    A 510 MB file from SenNet produced from OBI:0002631 as part of the TMC UConn Health project

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