SNT878.CMKL.622 (Collection)

Taxon:

Homo sapiens

Taxonomy (Entity type)

Dcc Asset:

sennet c2m2 jun26.zip

Processed File (Entity type)

Dcc:

SenNet

DCC (Entity type)

Anatomy:

left lung

Anatomy (Entity type)

Persistent Id:https://doi.org/10.60586/SNT878.CMKL.622

Has Time Series Data:0

Description:Cellular senescence is a fundamental hallmark of aging, yet its spatial and cellular dynamics in human tissues remain incompletely understood. This study aims to elucidate the mechanisms and distribution of senescence across the human lung by leveraging advanced single-cell and spatial transcriptomic technologies. Using Xenium-based spatial transcriptomics, this dataset captures gene expression profiles at single-cell resolution within intact lung parenchyma, enabling the investigation of cellular composition, spatial organization, and senescence-associated molecular signatures. Profiling human tissue slides using the Xenium In Situ Spatial Gene Expression platform with the Segmentation Kit, together with the 10x hLung 289-gene panel and a custom 100-gene senescence panel, enables high-resolution mapping of transcriptomic profiles within intact tissue architecture.

Creation Time:2025-08-12 03:35:35.221000

Results found

Linked to

	Label	Description
	left lung Anatomy (Entity type)	Lung which consists of the left upper lobe and left lower lobe..
	morphology focus 0001.ome.tif File (Entity type)	A 1.77 GB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	morphology focus 0000.ome.tif File (Entity type)	A 852 MB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	transcript locations.csv File (Entity type)	A 765 MB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	BRP56976 L F S33127 R4 C1 Xenium.tissue-boundary.geojson File (Entity type)	A 2.49 KB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	cell feature matrix.h5 File (Entity type)	A 9.21 MB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	morphology focus 0003.ome.tif File (Entity type)	A 1.46 GB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	d7219d736784be1766c00ce1f3153b38-metadata.tsv File (Entity type)	A 1.11 KB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	contributors.tsv File (Entity type)	A 1.72 KB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project
	~$markers.csv File (Entity type)	A 165 B file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

left lung

Anatomy (Entity type)

Lung which consists of the left upper lobe and left lower lobe..

morphology focus 0001.ome.tif

File (Entity type)

A 1.77 GB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

morphology focus 0000.ome.tif

File (Entity type)

A 852 MB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

transcript locations.csv

File (Entity type)

A 765 MB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

BRP56976 L F S33127 R4 C1 Xenium.tissue-boundary.geojson

File (Entity type)

A 2.49 KB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

cell feature matrix.h5

File (Entity type)

A 9.21 MB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

morphology focus 0003.ome.tif

File (Entity type)

A 1.46 GB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

d7219d736784be1766c00ce1f3153b38-metadata.tsv

File (Entity type)

A 1.11 KB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

contributors.tsv

File (Entity type)

A 1.72 KB file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

~$markers.csv

File (Entity type)

A 165 B file from SenNet produced from OBI:0001985 as part of the TMC Duke University project

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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